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LIF-receptor, alfaunderenhet Svensk MeSH

Compare Products: Select up to 4 products. *Please select more than one item to compare gp130 Inhibitor, SC144 - Calbiochem; Synonym: gp130 Inhibitor, SC144 - Calbiochem, SC144; Linear Formula: C16H11FN6O · xHCl; find Sigma-Aldrich-5.06387 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003529, Hematopoietin_rcpt_Gp130_CS IPR013783, Ig-like_fold IPR010457, IgC2-like_lig-bd IPR015321, TypeI_recpt_CBD: Pfam i: View protein in Pfam PF00041, fn3, 2 hits PF09240, IL6Ra-bind, 1 hit PF06328, Lep_receptor_Ig, 1 hit: SMART i: View Gp130 (Q13514_HUMAN) Interleukin 6 signal transducer (Gp130, oncostatin M receptor) (Q17RA0_HUMAN) IL6ST nirs variant 5 (Q5FC03_HUMAN) IL6ST nirs variant 2 (Q5FC06_HUMAN) Members of the interleukin-6 (IL-6) family of proinflammatory cytokines, which includes IL-6 and IL-11, stimulate responses by binding to a complex of their cytokine-specific receptor and the gp130 signaling receptor. Both of these receptor subunits can be shed from the cell surface and regulate distinct mechanisms of gp130-mediated signaling. Lamertz et al . engineered a reductionist system 2000-02-08 · The gp130 gene comprises 17 exons and 16 introns. The positions of the exon-intron boundaries show good correlation to the functional/homology regions of gp130.

Gp130

The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. The Human CD130 (IL-6R-beta, gp130) ELISA is to be used for the in-vitro quantitative determination of soluble CD130 protein (gp130) in human serum, plasma Osteocytic gp130 is required for PTH to increase osteoblast numbers and bone formation in trabecular bone. Male mice were treated with hPTH (1–34) at 30 μg/ kg 18 Jul 2019 Signaling Through gp130 Compromises Suppressive Function in Human FOXP3 + Regulatory T Cells. Khalid Bin Dhuban1,2,3†, Sabrina The gene IL6ST encodes GP130, the common signal transducer of the IL-6 cytokine family consisting of 10 cytokines. Previous studies have identified Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome. / Chen, Yin Huai; Grigelioniene, Giedre; Newton, Phillip T.; Expansor GP130.

Interleukin-11 binds specific EF-hand proteins via their

GP130 is the shared receptor for members of the IL6 family of cytokines. Members of this family have been shown to enhance the survival of migratory (E10.5) or postmigratory (E12.5) murine primordial germ cells (PGCs) in culture; however, it is uncertain what role these cytokines play during PGC development in vivo. 16193 Ensembl ENSG00000136244 ENSMUSG00000025746 UniProt P05231 P08505 RefSeq (mRNA) NM_000600 NM_001318095 NM_001371096 NM_031168 NM_001314054 RefSeq (protein) NP_000591 NP_001305024 NP_001358025 NP_001300983 NP_112445 Location (UCSC) Chr 7: 22.73 – 22.73 Mb Chr 5: 30.01 – 30.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 6 (IL-6) is an interleukin that acts as Gp130 engagement leads to activation of Src and JAK/Tyk tyrosine kinases, as well as the STAT family of transcription factors (4, 5).

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Artikelnummer: GP130. Slut i lager. Meddela mig vid tillgänglighet. 373,87 kr -25%. 280,40 kr. LRC · 4 Juni 2012 · #5,308. Tja, eftersom den förra bilden gick så snabbt kan jag ta en till, som nog är lite svårare: gp130.jpg Father: Claes Erik Andersson Born: 1848, Sweden Marr: 1876 Died: 1912.

Names & Taxonomy i. Protein names i: Submitted name: Gp130 Imported. Gene names i: Name:gp130 2017-02-24 2021-03-26 Rabbit polyclonal CD130 (gp130) antibody. Validated in WB, IHC, Flow Cyt and tested in Mouse, Human. Cited in 6 publication(s).
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2.2 Cell proliferation assay L3.6plandAsPC-1cellswereseededin96-well plates(5,000 cells/well) and allowed to grow overnight. Next, cells were incubated with raloxifene in serum-free medium at 37 °C for 48 hours. Cell proliferation was determined using a Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy Jia Wei1,2, Ling Ma2, Yi-Hui Lai3, Ruijie Zhang2, Huameng Li4, Chenglong Li5 and Jiayuh Lin2* Abstract Background: Interleukin-11 (IL-11), a dominant IL-6 family cytokine, is involved in tumorigenesis, tumor progression and differentiation in colon cancer cells. 2020-07-27 · To further explore the role of gp130 in heart regeneration, we generated gp130 fl/fl mice, in which the 5′LoxP element was inserted into intron 16 to 17 and the 3′LoxP element into downstream of 3′-untranslated region; and conditional ablation of gp130 in cardiomyocytes was achieved by crossing Myh6-MerCreMer mice with gp130 fl/fl mice (Myh6-gp130 −/−) . gp130 deletion in gp130 is a ubiquitously expressed, signal‐transducing receptor that forms part of the receptor complex for several cytokines, including IL‐6, IL‐11, IL‐27, leukemia inhibitory factor, OSM, CNTF, cardiotrophin 1, and cardiotrophin‐like cytokine . gp130 was described initially in mice as a membrane‐bound glycoprotein, absent on Johana & Narquoise - Geispolsheim - GP130 GP130-KO cells transfected with GP130-p.N404Y were unable to up-regulate fibrinogen after stimulation with IL-6, whereas transfection of GP130-WT restored the response .

Clinical Perspective. What Is New? gp130 (glycoprotein CD130 | gp130 | interleukin-6 receptor subunit beta | membrane glycoprotein 130 | oncostatin-M receptor subunit alpha | interleukin 6 signal transducer (gp130, gp130-dimerizing stimulus upregulates kinase activity of JAK2 as revealed by immunocomplex kinase assay. Deletion or point mutation in the membrane- proximal 刺激により、gp130が二量体を形成するとともに、gp130に会合するJAKも相互接近し、JAKどうしをチロシンリン酸化することにより活性化するものと考えられ gp130はインターロイキン6およびインターロイキン6受容体と結合することにより二量体化し，JAKを活性化することで転写因子STAT3をリン酸化し， STAT3の研究成果のポイント. シグナル伝達分子、gp130を共有するIL-6ファミリーサイトカインの機能の重複性と特異性について自己免疫疾患を例に Munters is a global leader in energy-efficient air treatment and climate solutions. Contact us today to learn more about our products and solutions! For full functionality of this site it is necessary to enable JavaScript.
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Cochet gp130. 2012. Backhoe. Frankrike, Ile de France-regionen (95). 4 000 €. Glykoprotein 130 (även känt som gp130 , IL6ST , IL6-beta eller CD130 ) är ett transmembranprotein som är den grundande medlemmen i 3 gp130 in TNF-a expression sgp130 concentrations in the culture supernatants of PMN Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor individer med allvarlig depression.

Gene therapy with adenovirus-associated virus encoding constitutively activated gp130 promoted cardiomyocyte proliferation and heart regeneration in adult mice after myocardial infarction. Gp130/JAK/STAT Pathway Model Report { Generated by the Bio-PEPA Workbench {Maria Luisa Guerriero December 16, 2008 1 Bio-PEPA model bind gl l 1 = [k 1 gp130 LIF LIFR] 2021-03-31 Recombinant Human gp130/IL6ST Protein (Met1-Ile618) ECD 10974-HCCH is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human gp130/IL6ST protein for relevant bioassay and related research. 2019-02-08 As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
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Inflammation Flashcards Quizlet

What Is New? gp130 (glycoprotein CD130 | gp130 | interleukin-6 receptor subunit beta | membrane glycoprotein 130 | oncostatin-M receptor subunit alpha | interleukin 6 signal transducer (gp130, gp130-dimerizing stimulus upregulates kinase activity of JAK2 as revealed by immunocomplex kinase assay. Deletion or point mutation in the membrane- proximal 刺激により、gp130が二量体を形成するとともに、gp130に会合するJAKも相互接近し、JAKどうしをチロシンリン酸化することにより活性化するものと考えられ gp130はインターロイキン6およびインターロイキン6受容体と結合することにより二量体化し，JAKを活性化することで転写因子STAT3をリン酸化し， STAT3の研究成果のポイント. シグナル伝達分子、gp130を共有するIL-6ファミリーサイトカインの機能の重複性と特異性について自己免疫疾患を例に Munters is a global leader in energy-efficient air treatment and climate solutions. Contact us today to learn more about our products and solutions! For full functionality of this site it is necessary to enable JavaScript. Here are the instructions how to enable JavaScript in your web browser.